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KMID : 0377520150400010019
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Chung-Ang Journal of Medicine
2015 Volume.40 No. 1 p.19 ~ p.24
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A Case of Acute Hemolysis and Acute Renal Failure Associated with Hepatitis A Infection and Normal Glucose-6-phosphate Dehydrogenase Status
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Lee Un-Joo
Kim Kwang-Yeol
Kim Hee-Jun
Jung Hyun-Yon
Kim Hyoung-Su
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Abstract
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Viral hepatitis A is considered to be a self-limited disease without clinical sequel. Among the extrahepatic complication of acute viral A hepatitis, severe hemolysis and acute renal failure have been rarely reported. In Korea, a hemolytic anemia after hepatitis A infection was reported in a glucose-6-phosphate dehydrogenase (G6PD) deficiency patient, but the hemolytic anemia in a normal G6PD patient has not been reported yet. G6PD deficiency is the most common enzyme deficiency and it causes a spectrum of disease including neonatal hyperbilirubinemia, acute hemolysis, and chronic hemolysis. We describe a normal G6PD patient with acute hepatitis A who developed severe hemolytic anemia and acute renal failure. A 42-year-old male patient was transferred to our hospital for treatment of severe anemia and acute renal failure. He did not have any underlying disease and did not take a medication. Laboratory results were compatible with hemolytic anemia, however the additional studies for differential diagnosis of hemolytic anemia including glucose-6-phosphate dehydrogenase status, showed normal results. He was diagnosed with acute hepatitis A complicated by severe hemolytic anemia and acute renal failure, and recovered spontaneously with only supportive care. We recently experienced the normal G6PD patient with acute hemolytic anemia and acute renal failure, therefore, we report a case of such experience.
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KEYWORD
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Hemolysis, Hepatitis A, Acute renal failure
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